The business of chemistry helps create the chemical products that make us safer

The chemical industry has helped us create products that make us safer - at home, at work, at play, on the road, even on the battlefield. These innovative chemical products were developed by 544000 American workers, and with the continuous progress of new technologies, our lives are safer and safer.

The following is a list of some chemical products, which are produced by the chemical industry and affect our daily life:

Plastic seat belts, child safety seats and airbags have saved countless lives on the road.

LED traffic lights, reflective signs and foam filled impact drums help us to be more secure.

Medical equipment, X-rays, blood bags and drugs saved lives in the emergency room.

Cyclists, skiers, hikers, climbers and other outdoor enthusiasts rely on CFRP equipment and safety equipment, from skis and boots to goggles and ropes.

Lightweight bulletproof vests have saved lives in law enforcement and on the battlefield.

MRes, packaged in plastic, deliver food safely to our soldiers on the battlefield and then heat themselves through chemical reactions.

Fifteen chemical companies made the 2019 list

As a technology-intensive industry, fine chemical industry can reflect the level of chemical industry development and scientific and technological level of a country or region, and has become one of the important development directions of China's chemical industry.Recently, the China Chemical Industry Information And Information Association and the National Fine Chemical Raw Materials and Intermediates Industry Cooperation Group have released the 2019 Top 100 List of China's fine Chemical Industry. The following changes are noteworthy.

Comparing the 2018 and 2019 lists, 15 chemical companies, including Shandong Nuol Biotechnology Co., LTD., Chongqing Purple Light Chemical Co., LTD., And Rianlon Corporation, have entered the 2019 list, becoming new faces on the list of China's top 100 fine Chemicals companies.In particular, Shandong Nuoer Biotechnology Co., Ltd. successfully entered the top 50 for the first time, ranking no. 43 on the list.

There will be new enterprises, there will be failed enterprises.By comparison, 15 companies, including Kangde Xin Composite Material Group Co.,Ltd., Jiangsu Yabang Dye Co., and Henan Qingan Chemical Technology Co., have dropped out of the top 100 in 2019.Some of these 15 enterprises do not participate in the evaluation for various reasons;Some have problems in their own operations, including declining profitability, business transformation, etc.Some because financial data is false or get safety environmental protection to wait for punishment to be cancelled to participate in qualification.

A close comparison also shows that 52 chemical companies have improved their ranking in 2019 compared with 2018.For example, Shi Yao Group Co., Ltd. was pushed into the top three from the fourth place, ranking the third;Oak Holdings Jumped from no. 33 to No. 22, making it the most improved company on the list.In addition, Zhejiang Yangfan New Materials Co. Ltd. climbed from 79 in 2018 to 73 in 2019, Liansheng Chemical Group Co. Ltd. climbed from 84 to 77, and Hebei Jianxin Chemical Co., Ltd., from 100 to 96, are all companies that have risen fast on the list.

The rankings of 19 companies are down from 2018.CNNC Hua Yuan Titanium Co., Ltd. fell to 41 from 34, while Hebei Arno Biotechnology Co., Ltd. fell to 82 from 77.

As the leading enterprises in the fine chemical industry, the position of the top 10 chemical enterprises in the list has hardly changed. Only Shi Yao Group Co., Ltd. and Beijing Yingtaijia Biotechnology Co., Ltd. have exchanged the third and fourth positions in 2019, while Zhejiang Longsheng Group Co., Ltd. remains the first in the industry.First, Zhejiang Longsheng acquired global dye giant Dystar, identifying its technological and raw material advantages.Since then, the company has continued to increase investment in environmental protection facilities, gained the first opportunity, continued to rise in performance, and steadily occupied the top position in the industry.Also, it should be noted that Linc Sanonda Co.,Ltd, who ranked ninth in 2018, changed its name to Andomai in December last year, still ranked ninth in 2019.

Chemical Products N-Benzyloxycarbonyl-D-proline Safety Information

CAS No:6404-31-5

Formula:C13H15NO4

Synonyms:D-Z-PRO;Z-D-PRO-OH;Z-D-PROLINE;CBZ-D-PRO-OH;CBZ-D-PROLINE;N-Z-D-PROLINE;Z-D-PYRD(2)-OH;N-CBZ-D-PRO-OH;N-CBZ-D-PROLINE;(+)-Z-D-proline

China Export:From 2018.11 to 2019.11, total export volume of N-Benzyloxycarbonyl-D-proline from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.

Chemical Products N-Benzyloxycarbonyl-D-proline Description

White crystalline powder or powder

Chemical Products N-Benzyloxycarbonyl-D-proline Basic Attributes

CAS No：6404-31-5

Molecular Formula ：C13H15NO4

Molecular Mass ：249.26

Exact Mass ：249.100113

PSA ：66.8 A^2

LogP ：1.7

EINECS ：229-021-5

InChIKeys ：JXGVXCZADZNAMJ-LLVKDONJSA-N

H-bond Acceptor ：4

H-bond Donor ：1

SP3 ：0.38

RBN ：4

Chemical Products N-Benzyloxycarbonyl-D-proline Characteristics

Appearance ：White Crystalline Powder or Powder

Density ：1.3±0.1 g/cm3

Melting Point ：76-78 °C(lit.)

Bolling Point ：432.3°C at 760 mmHg

Flash Point ：215.3±28.7 °C

Refractive Index ：1.582

Storage Condition ：Store at RT.

BRN ：485188

Specific Rotation ：40 º (c=2, EtOH)

Chemical Products N-Benzyloxycarbonyl-D-proline Safety Information

HS Code ：29339900

UN No. ：NONH for all modes of transport

WGK_Germany ：3

Safety Instructions ：24/25

Dangerous Mark ：Xi

P Code ：P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements ：H315

Chemical Products N-Benzyloxycarbonyl-D-proline Production Methods

Step-1 : Preparation of (R)-l-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a) To a stirred solution of D-Proline (1.2 g, 10.42 mmol) in 2 N aqueous NaOH solution (20.85 mL, 41.7 mmol) at 0 °C was added benzyl chloroformate (1.488 mL, 10.42 mmol) and allowed to warm to room temperature overnight. The reaction was washed with MTBE (2 x 25 mL), acidified with cone HCl and extracted with ethyl acetate (2 x 200 mL). The ethyl acetate layers were combined washed with water (50 mL), brine (25 mL) dried and concentrated in vacuum to afford (R)-l-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a) (2.41 g, 9.67 mmol, 93 percent yield) which was used as such in next step; Η NMR (300 MHz, DMSO-i) δ 12.66 (s, 1H), 7.42 - 7.25 (m, 5H), 5.14 - 4.97 (m, 2H), 4.20 (ddd, J = 22.7, 8.8, 3.5 Hz, 1H), 3.50 - 3.25 (m, 2H), 2.32 - 2.08 (m, 1H), 1.97 - 1.75 (m, 3H); MS (ES+) 250.2 (M+l), 272.2 (M+Na), (ES-) 248.2 (M-l), 284.2 (M+Cl), 497.4 (2M-1).20.0mmol D-valine was dissolved in 12.0mL, 2mol/L NaOH solution, 22mmol benzyl chloroformate was added dropwise at 0 °C, then added with NaOH solution, extracted, washed, dried, concentrated, separated by silica gel column. Got(R)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid in a yield of 95percent.

Chemical Products FMOC-L-Leucine Safety Information

CAS No:35661-60-0

Formula:C21H23NO4

Synonyms:FMOC-LEU-OH;FMOC-L-LEU-OH;FMOC-L-LEU;FMOC-L-LEUCINE;F-L-LEU;Fmoc-L-leucine,98%;L-Leucine-1-13C-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine

China Export:From 2018.11 to 2019.11, total export volume of FMOC-L-Leucine from China was 76,865,630KG while total export value was $825,816,556. The biggest proportion of exporting volume in the last 12 months was 14.24% in 2019.05.

Chemical Products FMOC-L-Leucine Description

white to light yellow crystal powde

Chemical Products FMOC-L-Leucine Basic Attributes

CAS No：35661-60-0

Molecular Formula ：C21H23NO4

Molecular Mass ：353.41

Exact Mass ：353.162720

PSA ：75.6 A^2

LogP ：4.4

EINECS ：252-662-7

InChIKeys ：CBPJQFCAFFNICX-IBGZPJMESA-N

H-bond Acceptor ：4

H-bond Donor ：2

SP3 ：0.33

RBN ：7

Chemical Products FMOC-L-Leucine Characteristics

Density ：1.2±0.1 g/cm3

Melting Point ：152-156 °C(lit.)

Bolling Point ：559.8°C at 760 mmHg

Flash Point ：292.4±25.4 °C

Refractive Index ：1.583

Storage Condition ：2-8°C

BRN ：2178254

Specific Rotation ：-26 º (c=1,DMF 24 ºC)

Chemical Products FMOC-L-Leucine Safety Information

HS Code ：2924299090

UN No. ：NONH for all modes of transport

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：22-24/25-36/37/39-27-26

Dangerous Mark ：Xi

P Code ：P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements ：H302

Chemical Products FMOC-L-Leucine Production Methods

General procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.EXAMPLE 22