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显示标签为“Chemical Products”的博文。显示所有博文

2020年12月1日星期二

The role of specialty chemical products distributors

In the past few years, the role of special chemical products distributors has changed, which mainly affects the whole value chain of chemical products. In the past, chemical manufacturers used to see professional distributors as a necessary evil - a means to reach small customers or customers who were difficult to serve economically. Today, distributors are becoming an important part of the channel. The best dealers have deep market insight and the ability to create real value for manufacturers and customers. No wonder the market for specialty chemicals continues to grow faster than the industry as a whole.


We have recently conducted a comprehensive analysis of the sales market of specialty chemicals to identify promising markets and market segments, and to determine the development trend of the industry in the near future. (for similar analysis, see BCG report, distribution of specialty chemicals in North America, March 2016; market dynamics of specialty chemicals distribution, Boston Consulting Report, April 2014. )The central conclusion of our analysis is that although the market is still very attractive, the threshold for the success of professional dealers is constantly increasing.





From 2012 to 2017, the distribution of specialty chemical products grew at a compound annual growth rate (CAGR) of 5.6%, with a global market size of about 97 billion euros. This is faster than GDP (2.7%), chemical industry (2.9%) and special chemicals consumption (4.9%) in the same period. However, to develop competitive advantage, scale itself can not solve the problem. Instead, professional distributors need to select specific market segments and geographic regions and then invest in the capabilities necessary to enable them to create value for chemical manufacturers and end users in these segments.


Moreover, digital technology is becoming crucial. Due to the high complexity of technology and logistics requirements, it is less destructive than other industries, but customers increasingly expect a complete online and offline experience. As a result, professional chemical products distributors must begin to invest in digital solutions, both in-house and customer-oriented operations, to expand their competitive advantage.


As of 2017, the largest markets were the Asia Pacific region (sales of professional distributors were around 40 billion euros), North America (31 billion euros) and Western Europe (13 billion euros). The rest of the market is less than 5 billion euros. The Asia Pacific region is not only the world's largest distribution market for specialty chemicals, but also one of the fastest growing regions, with a CAGR of 6.8% from 2012 to 2017. During this period, only the Middle East grew faster (7.8%). In contrast, growth in most developed markets has slowed, as expected, over the past five years: 4.7% in North America and 3.6% in Western Europe.


We expect sales growth of specialty chemicals to slow slightly to 5% by 2022, due to slower consumption of chemicals (for the industry as a whole and a subset of specialty chemicals), reduced demand in mature Western markets, and short-term setbacks in the Chinese economy. However, it will still outpace overall global GDP growth and specialty chemicals sales in major markets. (see Table 1. )In absolute terms, most of the growth in third-party distribution of specialty chemicals will come from major markets in Asia Pacific and North America by 2022.

2020年11月25日星期三

The business of chemistry helps create the chemical products that make us safer

The chemical industry has helped us create products that make us safer - at home, at work, at play, on the road, even on the battlefield. These innovative chemical products were developed by 544000 American workers, and with the continuous progress of new technologies, our lives are safer and safer.


The following is a list of some chemical products, which are produced by the chemical industry and affect our daily life:


Plastic seat belts, child safety seats and airbags have saved countless lives on the road.


LED traffic lights, reflective signs and foam filled impact drums help us to be more secure.


Medical equipment, X-rays, blood bags and drugs saved lives in the emergency room.


Cyclists, skiers, hikers, climbers and other outdoor enthusiasts rely on CFRP equipment and safety equipment, from skis and boots to goggles and ropes.





Lightweight bulletproof vests have saved lives in law enforcement and on the battlefield.


MRes, packaged in plastic, deliver food safely to our soldiers on the battlefield and then heat themselves through chemical reactions.

2020年11月11日星期三

Chemical Products N-Benzyloxycarbonyl-D-proline Safety Information

CAS No:6404-31-5

Formula:C13H15NO4

Synonyms:D-Z-PRO;Z-D-PRO-OH;Z-D-PROLINE;CBZ-D-PRO-OH;CBZ-D-PROLINE;N-Z-D-PROLINE;Z-D-PYRD(2)-OH;N-CBZ-D-PRO-OH;N-CBZ-D-PROLINE;(+)-Z-D-proline

China Export:From 2018.11 to 2019.11, total export volume of N-Benzyloxycarbonyl-D-proline from China was 112,377,052KG while total export value was $2,146,929,254. The biggest proportion of exporting volume in the last 12 months was 9.88% in 2019.03.


Chemical Products N-Benzyloxycarbonyl-D-proline Description

White crystalline powder or powder


Chemical Products N-Benzyloxycarbonyl-D-proline Basic Attributes

CAS No:6404-31-5


Molecular Formula :C13H15NO4


Molecular Mass :249.26


Exact Mass :249.100113


PSA :66.8 A^2


LogP :1.7


EINECS :229-021-5


InChIKeys :JXGVXCZADZNAMJ-LLVKDONJSA-N


H-bond Acceptor :4


H-bond Donor :1


SP3 :0.38


RBN :4


Chemical Products N-Benzyloxycarbonyl-D-proline Characteristics

Appearance :White Crystalline Powder or Powder


Density :1.3±0.1 g/cm3


Melting Point :76-78 °C(lit.)


Bolling Point :432.3°C at 760 mmHg


Flash Point :215.3±28.7 °C


Refractive Index :1.582


Storage Condition :Store at RT.


BRN :485188


Specific Rotation :40 º (c=2, EtOH)





Chemical Products N-Benzyloxycarbonyl-D-proline Safety Information

HS Code :29339900


UN No. :NONH for all modes of transport


WGK_Germany :3


Safety Instructions :24/25


Dangerous Mark :Xi


P Code :P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501


Hazard Statements :H315


Chemical Products N-Benzyloxycarbonyl-D-proline Production Methods

Step-1 : Preparation of (R)-l-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a) To a stirred solution of D-Proline (1.2 g, 10.42 mmol) in 2 N aqueous NaOH solution (20.85 mL, 41.7 mmol) at 0 °C was added benzyl chloroformate (1.488 mL, 10.42 mmol) and allowed to warm to room temperature overnight. The reaction was washed with MTBE (2 x 25 mL), acidified with cone HCl and extracted with ethyl acetate (2 x 200 mL). The ethyl acetate layers were combined washed with water (50 mL), brine (25 mL) dried and concentrated in vacuum to afford (R)-l-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (12a) (2.41 g, 9.67 mmol, 93 percent yield) which was used as such in next step; Η NMR (300 MHz, DMSO-i) δ 12.66 (s, 1H), 7.42 - 7.25 (m, 5H), 5.14 - 4.97 (m, 2H), 4.20 (ddd, J = 22.7, 8.8, 3.5 Hz, 1H), 3.50 - 3.25 (m, 2H), 2.32 - 2.08 (m, 1H), 1.97 - 1.75 (m, 3H); MS (ES+) 250.2 (M+l), 272.2 (M+Na), (ES-) 248.2 (M-l), 284.2 (M+Cl), 497.4 (2M-1).20.0mmol D-valine was dissolved in 12.0mL, 2mol/L NaOH solution, 22mmol benzyl chloroformate was added dropwise at 0 °C, then added with NaOH solution, extracted, washed, dried, concentrated, separated by silica gel column. Got(R)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid in a yield of 95percent.

2020年11月3日星期二

Chemical Products FMOC-L-Leucine Safety Information

CAS No:35661-60-0

Formula:C21H23NO4

Synonyms:FMOC-LEU-OH;FMOC-L-LEU-OH;FMOC-L-LEU;FMOC-L-LEUCINE;F-L-LEU;Fmoc-L-leucine,98%;L-Leucine-1-13C-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine

China Export:From 2018.11 to 2019.11, total export volume of FMOC-L-Leucine from China was 76,865,630KG while total export value was $825,816,556. The biggest proportion of exporting volume in the last 12 months was 14.24% in 2019.05.


Chemical Products FMOC-L-Leucine Description

white to light yellow crystal powde


Chemical Products FMOC-L-Leucine Basic Attributes

CAS No:35661-60-0


Molecular Formula :C21H23NO4


Molecular Mass :353.41


Exact Mass :353.162720


PSA :75.6 A^2


LogP :4.4


EINECS :252-662-7


InChIKeys :CBPJQFCAFFNICX-IBGZPJMESA-N


H-bond Acceptor :4


H-bond Donor :2


SP3 :0.33


RBN :7





Chemical Products FMOC-L-Leucine Characteristics

Density :1.2±0.1 g/cm3


Melting Point :152-156 °C(lit.)


Bolling Point :559.8°C at 760 mmHg


Flash Point :292.4±25.4 °C


Refractive Index :1.583


Storage Condition :2-8°C


BRN :2178254


Specific Rotation :-26 º (c=1,DMF 24 ºC)


Chemical Products FMOC-L-Leucine Safety Information

HS Code :2924299090


UN No. :NONH for all modes of transport


WGK_Germany :3


Risk Code :36/37/38


Safety Instructions :22-24/25-36/37/39-27-26


Dangerous Mark :Xi


P Code :P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501


Hazard Statements :H302


Chemical Products FMOC-L-Leucine Production Methods

General procedure: To a solution of H-Phe-OH (100 mg, 60.5 mmol) in 50 percent MeCN (6.1 mL)were added Fmoc-OPhth (233 mg, 60.5 mmol) and K2CO3 (167 mg, 121 mmol) and stirred at room temperature. After 2 h of stirring saturated sodium bicarbonate solution and H2O were added and the resulting solution was washed with diethyl ether. The aqueous phase is acidified to pH 1 with 1M HCl and extracted with diethyl ether. The organic phase was washed with 1 M HCl, H2O, brine, dried over MgSO4. The filtrate was evaporatedevaporated under reduced pressure to give yellow solid as crude product.EXAMPLE 22

2020年9月9日星期三

Chemical Products 1-Bromo-2,5-difluorobenzene Description

Chemical Products 1-Bromo-2,5-difluorobenzene Description

CLEAR COLOURLESS LIQUID


Chemical Products 1-Bromo-2,5-difluorobenzene Basic Attributes

CAS No:399-94-0


Molecular Formula :C6H3BrF2


Molecular Mass :192.99


Exact Mass :191.938614


PSA :0 A^2


LogP :3


EINECS :206-920-0


InChIKeys :XCRCSPKQEDMVBO-UHFFFAOYSA-N


H-bond Acceptor :2


H-bond Donor :0


SP3 :0.00


RBN :0


Chemical Products 1-Bromo-2,5-difluorobenzene Characteristics

Density :1.7±0.1 g/cm3


Melting Point :−31 °C(lit.)


Bolling Point :58-59 °C20 mm Hg(lit.)


Flash Point :149 °F


Refractive Index :1.507


Solubility :H2O: Insoluble


BRN :1680893


Chemical Products 1-Bromo-2,5-difluorobenzene Safety Information

Hazard Class :IRRITANT, FLAMMABLE


HS Code :29039990


UN No. :UN2922


WGK_Germany :3


Risk Code :36/37/38


Safety Instructions :26-36/37/39-2637/39-37/39


Dangerous Mark :Xi,F,Xn


P Code :P261-P305 + P351 + P338


Hazard Statements :H315-H319-H335


Hazard Note :Flammable


Chemical Products 1-Bromo-2,5-difluorobenzene Product Usage

Used as medicine, pesticide, liquid crystal material intermediate


Chemical Products 1-Bromo-2,5-difluorobenzene Production Methods

General procedure: A FEP or PFA reactor equipped with a Teflon-lined magnetic stir bar and connected to a gas-washing bottle was charged with substituted benzene (0.95–1.10 mmol), 1, 1, 1, 3, 3-pentafluorobutane (1–2 mL per mmol of C6H5R), and BF3 · Et2O (1.3–1.5 mmol per mmol of C6H5R). The mixture was stirred for 10–15 min at 0–5°C (ice bath), and XeF2 (1.2–1.3 mmol per mmol of C6H5R) was added in portions. After addition of each portion, the mixture was stirred for 3–5 min at 22–25°C and cooled again. When the addition was complete the dark solution was stirred for 15–30 min at 22–25°C, 10percent aqueous KHCO3 was added, and the upper organic layer was separated, passed through a short column charged with silica gel (40–60 μm), and dried over MgSO4. The solution was analyzed by 19F NMR and GC/MS. The main products are given in table, and the others are listed below (GC/MS data).

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